Stevia "Otra verdad incomoda"

Estudios Científicos que incomodan !!

Para corroborar de una forma científica las propiedades de la Stevia en enfermedades como la diabétes y la hipetensión, he encontrado , con la colaboración de mi hija que es médico de familia, estudios publicados en ingles en las enciclopedias de consulta médica internacional,MEDLINE y COCHRANE con resultados positivos tanto en experimentación con ratas como en humanos.

Para muchas personas diabéticas e hipertensas que no dominen el ingles , como es mi caso , quizás no les sirva de mucho , pero al menos puede que sirva para que mas médicos se interesen por el tema y colaboren en combinar medicación convencional con administración de Stevia y mejorar considerablemente la calidad de vida de muchas personas afectadas por dichas enfermedades.

A continuacion adjunto dichos estudios:

Antihyperglycemic effects of stevioside in type 2 diabetic subjects.
Authors Gregersen S, Jeppesen PB, Holst JJ, Hermansen K
Source Metabolism: clinical and experimental
Date of publication 2004 Jan
Volume 53
Issue 1
Pages 73-6

Abstract

Stevioside is present in the plant Stevia rebaudiana Bertoni (SrB). Extracts of SrB have been used for the treatment of diabetes in, for example, Brazil, although a positive effect on glucose metabolism has not been unequivocally demonstrated. We studied the acute effects of stevioside in type 2 diabetic patients. We hypothesize that supplementation with stevioside to a test meal causes a reduction in postprandial blood glucose. Twelve type 2 diabetic patients were included in an acute, paired cross-over study. A standard test meal was supplemented with either 1 g of stevioside or 1 g of maize starch (control). Blood samples were drawn at 30 minutes before and for 240 minutes after ingestion of the test meal. Compared to control, stevioside reduced the incremental area under the glucose response curve by 18% (P =.013). The insulinogenic index (AUC(i,insulin)/AUC(i,glucose)) was increased by approximately 40% by stevioside compared to control (P <.001). Stevioside tended to decrease glucagon levels, while it did not significantly alter the area under the insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic polypeptide curves. In conclusion, stevioside reduces postprandial blood glucose levels in type 2 diabetic patients, indicating beneficial effects on the glucose metabolism. Stevioside may be advantageous in the treatment of type 2 diabetes.
Medical Subject Headings (MeSH) Blood Glucose [analysis]; Cross-Over Studies; Diabetes Mellitus, Type 2 [blood]; *Diabetes Mellitus, Type 2 [drug therapy]; Diabetes Mellitus, Type 2 [urine]; Diterpenes [administration & dosage]; *Diterpenes [therapeutic use]; *Diterpenes, Kaurane; Diuresis; Fatty Acids, Nonesterified [blood]; Food; Gastric Inhibitory Polypeptide [blood]; Glucagon [blood]; Glucagon-Like Peptide 1; Glucosides [administration & dosage]; *Glucosides [therapeutic use]; Glycosuria; Hemoglobin A, Glycosylated [analysis]; Hypoglycemic Agents [administration & dosage]; *Hypoglycemic Agents [therapeutic use]; Insulin [blood]; Kinetics; Peptide Fragments [blood]; Placebos; Protein Precursors [blood]; Triglycerides [blood]
Mesh check words: • Aged • Female • Humans • Male • Middle AgedCorrespondence address Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark.
Accession Number PUBMED 14681845
Publication type Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov’t
ID CN-00459659

Available Links PubMed

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Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study.
Authors Hsieh MH, Chan P, Sue YM, Liu JC, Liang TH, Huang TY, Tomlinson B, Chow MS, Kao PF, Chen YJ
Source Clinical therapeutics
Date of publication 2003 Nov
Volume 25
Issue 11
Pages 2797-808
Abstract

BACKGROUND: Stevioside, a natural glycoside isolated from the plant Stevia rebaudiana Bertoni, has been used as a commercial sweetening agent in Japan and Brazil for >20 years. Previous animal and human studies have indicated that stevioside has an antihypertensive effect. OBJECTIVES: This study was undertaken to investigate the long-term (2-year) efficacy and tolerability of stevioside in patients with mild essential hypertension. Secondary objectives were to determine the effects of stevioside on left ventricular mass index (LVMI) and quality of life (QOL). METHODS: This was a multicenter, randomized, double-blind, placebo-controlled trial in Chinese men and women aged between 20 and 75 years with mild essential hypertension (systolic blood pressure [SBP] 140-159 mm Hg and diastolic blood pressure [DBP] 90-99 mm Hg). Patients took capsules containing 500 mg stevioside powder or placebo 3 times daily for 2 years. Blood pressure was measured at monthly clinic visits; patients were also encouraged to monitor blood pressure at home using an automated device. LVMI was determined by 2-dimensional echocardiography at baseline and after 1 and 2 years of treatment. QOL was assessed using the Medical Outcomes Study 36-Item Short-Form Health Survey. Electrocardiographic, laboratory, and QOL parameters were assessed at the beginning of treatment, and at 6 months, 1 year, and 2 years. RESULTS: One hundred seventy-four patients (87 men, 87 women) were enrolled in the study, and 168 completed it: 82 (42 men, 40 women; mean [SD] age, 52 [7] years) in the stevioside group and 86 (44 women, 42 men; mean age, 53 [7] years) in the placebo group. After 2 years, the stevioside group had significant decreases in mean (SD) SBP and DBP compared with baseline (SBP, from 150 [7.3] to 140 [6.8] mm Hg; DBP, from 95 [4.2] to 89 [3.2] mm Hg; P < 0.05) and compared with placebo (P < 0.05). Based on patients’ records of self-monitored blood pressure, these effects were noted beginning approximately 1 week after the start of treatment and persisted throughout the study. There were no significant changes in body mass index or blood biochemistry, and the results of laboratory tests were similar in the 2 groups throughout the study. No significant difference in the incidence of adverse effects was noted between groups, and QOL scores were significantly improved overall with stevioside compared with placebo (P < 0.001). Neither group had a significant change in mean LVMI. However, after 2 years, 6 of 52 patients (11.5%) in the stevioside group had left ventricular hypertrophy (LVH), compared with 17 of 50 patients (34.0%) in the placebo group (P < 0.001). Of those who did not have LVH at baseline, 3 of 46 patients (6.5%) in the stevioside group had developed LVH after 2 years, compared with 9 of 37 patients (24.3%) in the placebo group (P < 0.001). CONCLUSIONS: In this 2-year study in Chinese patients with mild hypertension, oral stevioside significantly decreased SBP and DBP compared with placebo. QOL was improved, and no significant adverse effects were noted.
Medical Subject Headings (MeSH) Administration, Oral; Antihypertensive Agents [adverse effects]; *Antihypertensive Agents [therapeutic use]; Blood Pressure [drug effects]; Diterpenes [adverse effects]; *Diterpenes [therapeutic use]; *Diterpenes, Kaurane; Double-Blind Method; Glucosides [adverse effects]; *Glucosides [therapeutic use]; Hypertension [complications]; *Hypertension [drug therapy]; Hypertrophy, Left Ventricular [etiology]; Quality of Life
Mesh check words: • Adult • Aged • Female • Humans • Male • Middle AgedCorrespondence address Department of Medicine, Taipei Medical University–Wan Fang Hospital, Taipei City, Taiwan.
Accession Number PUBMED 14693305

Publication type Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
ID CN-00472545
Available Links PubMed

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A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension.
Authors Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JT
Source British journal of clinical pharmacology
Date of publication 2000 Sep
Volume 50
Issue 3
Pages 215-20
Abstract

AIMS: Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the effect of stevioside in human hypertension. METHODS: A multicentre, randomized, double-blind, placebo-controlled study was undertaken. This study group consisted of 106 Chinese hypertensive subjects with diastolic blood pressure between 95 and 110 mmHg and ages ranging from 28 to 75 years with 60 subjects (men 34, women 26; mean +/- s.d., 54.1+/-3.8 years) allocated to active treatment and 46 (men 19, women 27; mean +/- s.d., 53.7+/-4.1 years) to placebo treatment. Each subject was given capsules containing stevioside (250 mg) or placebo thrice daily and followed-up at monthly intervals for 1 year. RESULTS: After 3 months, the systolic and diastolic blood pressure of the stevioside group decreased significantly (systolic: 166.0+/-9.4-152.6+/-6.8 mmHg; diastolic: 104.7 +/- 5.2-90.3+/-3.6 mmHg, P<0.05), and the effect persisted during the whole year. Blood biochemistry parameters including lipid and glucose showed no significant changes. No significant adverse effect was observed and quality of life assessment showed no deterioration. CONCLUSIONS: This study shows that oral stevioside is a well tolerated and effective modality that may be considered as an alternative or supplementary therapy for patients with hypertension.
Medical Subject Headings (MeSH) Antihypertensive Agents [adverse effects]; *Antihypertensive Agents [therapeutic use]; *Diterpenes; *Diterpenes, Kaurane; Double-Blind Method; Glucosides [adverse effects]; *Glucosides [therapeutic use]; *Hypertension [drug therapy]; Hypertension [physiopathology]; Hypertension [psychology]; Patient Compliance; Quality of Life; Terpenes [adverse effects]; *Terpenes [therapeutic use]
Mesh check words: • Adult • Aged • Female • Humans • Male • Middle AgedCorrespondence address Division of Cardiovascular Medicine, Taipei Medical College and affiliated Taipei Wan Fang Hospital, Taiwan.

Accession Number PUBMED 10971305
Publication type Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
ID CN-00331990
Available Links PubMed

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Effect of Stevia rebaudiana on glucose tolerance in normal adult humans.
Curi R, Alvarez M, Bazotte RB, Botion LM, Godoy JL, Bracht A.
Departamento de Farmácia-Bioquímica, Universidade de Maringá, Brasil.
The effect of aqueous extracts of Stevia rebaudiana leaves on a glucose tolerance test was investigated in 16 normal volunteers. Aqueous extracts of 5 grams of leaves were administered to volunteers at regular 6-h intervals for 3 days. Glucose tolerance tests were performed before and after extract administration. A second group of 6 normal volunteers who ingested an aqueous arabinose solution was also studied to eliminate possible stress effects. The extract of Stevia rebaudiana increased glucose tolerance. The extract significantly decreased plasma glucose levels during the test and after overnight fasting in all volunteers.
PMID: 3651629 [PubMed - indexed for MEDLINE]
Related Links
• Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. [J Ethnopharmacol. 1995]
• A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. [Braz J Med Biol Res. 1996]
• Glucose concentration in the blood of intact and alloxan-treated mice after pretreatment with commercial preparations of Stevia rebaudiana (Bertoni). [Eur J Drug Metab Pharmacokinet. 2004]
• Joint effect of commercial preparations of Stevia rebaudiana Bertoni and sodium monoketocholate on glycemia in mice. [Eur J Drug Metab Pharmacokinet. 2004]
• Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. [Planta Med. 2005]
See all Related Articles…: Planta Med. 2006 Jun;72(8):691-6. Epub 2006 May 29.

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Comparative effects of Stevia rebaudiana leaves and stevioside on glycaemia and hepatic gluconeogenesis.
Ferreira EB, de Assis Rocha Neves F, da Costa MA, do Prado WA, de Araújo Funari Ferri L, Bazotte RB.
Department of Pharmacy and Pharmacology, State University of Maringá, Maringá-Pr, Brazil.
The purpose of the present study was to compare the effect of the oral treatment (gavage) with Stevia rebaudiana (Bert.) Bertoni (SRB) and stevioside (STV) on glycaemia and gluconeogenesis of 15-h fasted rats. For this purpose, the rats received SRB (20 mg/kg x day), STV (5.5 mg/kg x day) or an equal volume of water (controls) during 15 days. To measure hepatic gluconeogenesis, liver perfusion and isolated hepatocytes were used. Glycaemia and gluconeogenesis from L-alanine (5 mM), L-glutamine (5 mM) and L-lactate (2 mM) were decreased (P < 0.05) after pre-treatment with SRB. However, the treatment with STV did not influence glycaemia and gluconeogenesis. Moreover, to get further information about the mechanism by which SRB leaves inhibit gluconeogenesis their potential role as a PPARgamma agonist was investigated. The data showed absence of activation of PPARgamma receptors. In summary, our results showed that the reduction of glycaemia promoted by the treatment with SRB leaves was mediated, at least in part, by an inhibition of hepatic gluconeogenesis. However, this effect did not involve stevioside and the activation of PPARgamma receptors.
PMID: 16732523 [PubMed - indexed for MEDLINE]

Related Links
• Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. [Phytomedicine. 2002]
• Influence of stevioside on hepatic glycogen levels in fasted rats. [Res Commun Chem Pathol Pharmacol. 1994]
• Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. [Horm Metab Res. 2005]
• Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. [Planta Med. 2005]
• Glucose concentration in the blood of intact and alloxan-treated mice after pretreatment with commercial preparations of Stevia rebaudiana (Bertoni). [Eur J Drug Metab Pharmacokinet. 2004]
See all Related Articles…Horm Metab Res. 2005 Oct;37(10):610-6.

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Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats.
Chang JC, Wu MC, Liu IM, Cheng JT.
Department of Food Science, National Pingtung University of Science and Technology, Pingtung City, Taiwan, R.O.C.
The intake of dietary fructose has undergone a marked increase around the world, especially the developed countries, in recent times. Stevioside, a glycoside contained in the leaves of Stevia rebaudiana Bertoni (Compositae), was used to screen the effect induced by a diet containing 60% fructose on insulin resistance in rats. Single oral administration of stevioside for 90 min decreased plasma glucose concentrations in a dose-dependent manner in rats receiving fructose-rich chow for four weeks. In addition, insulin action on glucose disposal rate was measured using the glucose-insulin index, the product of the areas under the curve of glucose, and insulin during the intraperitoneal glucose tolerance test. Oral administration of stevioside (5.0 mg/kg) in rats given four weeks of fructose-rich chow for 90 min reversed the value of glucose-insulin index, indicating that stevioside has the ability to improve insulin sensitivity in this insulin-resistant animal model. Time for the loss of plasma glucose lowering response to tolbutamide (10.0 mg/kg, i. p.) in fructose-rich chow fed rats was also markedly delayed by repeated stevioside treatment three times daily compared to the vehicle-treated group. The plasma glucose-lowering activity of tolbutamide was introduced to account for varying levels of endogenous insulin secretion, and is widely used as the indicator of insulin resistance development. Thus, it provided the supportive data that repeated oral administration of stevioside delayed the development of insulin resistance in rats on a high-fructose diet. Increased insulin sensitivity by stevioside administration was further identified using the plasma glucose-lowering action of exogenous insulin in streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral administration of stevioside at 0.2 mg/kg three times daily into STZ-diabetic rats for ten days increased the response to exogenous insulin. Taken together, this demonstrated that oral administration of stevioside improves insulin sensitivity, and seems suitable as an adjuvant for diabetic patients and/or those that consume large amounts of fructose.
PMID: 16278783 [PubMed - indexed for MEDLINE]
Related Links
• Improvement of insulin resistance by miracle fruit (Synsepalum dulcificum) in fructose-rich chow-fed rats. [Phytother Res. 2006]
• Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats. [Clin Exp Pharmacol Physiol. 2005]
• Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. [Horm Metab Res. 2007]
• Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats. [Horm Metab Res. 2005]
• Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. [Phytomedicine. 2002]
See all Related Articles…

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1: Planta Med. 2005 Feb;71(2):108-13.

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Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana.
Chen TH, Chen SC, Chan P, Chu YL, Yang HY, Cheng JT.
Department of Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan.
We have studied the effects of stevioside on the glucose and insulin metabolism in 2 models of diabetes in rats, STZ-induced diabetic rats and NIDDM diabetic rats induced by feeding with fructose. Stevioside (0.5 mg/kg), lowered the blood glucose levels in STZ-induced diabetic rats, peaking at 90 min. Stevioside administered twice daily also demonstrated dose-dependent effects in lowering the glucose levels in both diabetic rat models. Stevioside reduced the rise in glucose during glucose tolerance testing in normal rats. Stevioside dose-dependently decreased protein levels of phosphoenol pyruvate carboxykinase (PEPCK) and PEPCK mRNA after 15 days of treatment. Stevioside also reduced insulin resistance in the diabetic animals as shown by the glucose lowering effects of tolbutamide. In conclusion, stevioside was able to regulate blood glucose levels by enhancing not only insulin secretion, but also insulin utilization in insulin-deficient rats; the latter was due to decreased PEPCK gene expression in rat liver by stevioside’s action of slowing down gluconeogenesis. Further studies of this agent for the treatment of diabetes appear warranted.
PMID: 15729617 [PubMed - indexed for MEDLINE]
Related Links
• Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. [Horm Metab Res. 2005]
• Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. [Phytomedicine. 2002]
• Comparative effects of Stevia rebaudiana leaves and stevioside on glycaemia and hepatic gluconeogenesis. [Planta Med. 2006]
• Metformin-like effects of Quei Fu Di Huang Wan, a Chinese herbal mixture, on streptozotocin-induced diabetic rat. [Horm Metab Res. 2001]
• Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats. [J Hypertens. 2003]
See all Related Articles…

1: Metabolism. 2003 Mar;52(3):372-8. Links

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Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat.
Jeppesen PB, Gregersen S, Rolfsen SE, Jepsen M, Colombo M, Agger A, Xiao J, Kruhøffer M, Orntoft T, Hermansen K.
Department of Endocrinology and Metabolism, Molecular Diagnostic Laboratory, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark.
Stevioside, a glycoside present in the leaves of the plant, Stevia rebaudiana Bertoni (SrB), has acute insulinotropic effects in vitro. Its potential antihyperglycemic and blood pressure-lowering effects were examined in a long-term study in the type 2 diabetic Goto-Kakizaki (GK) rat. Rats were fed 0.025 g x kg(-1) x d(-1) of stevioside (purity > 99.6%) for 6 weeks. An intra-arterial catheter was inserted into the rats after 5 weeks, and conscious rats were subjected to arterial glucose tolerance test (2.0 g x kg(-1)) during week 6. Stevioside had an antihyperglycemic effect (incremental area under the glucose response curve [IAUC]): 985 +/- 20 (stevioside) versus 1,575 +/- 21 (control) mmol/L x 180 minutes, (P <.05), it enhanced the first-phase insulin response (IAUC: 343 +/- 33 [stevioside] v 136 +/- 24 [control] microU/mL insulin x 30 minutes, P <.05) and concomitantly suppressed the glucagon levels (total AUC: 2,026 +/- 234 [stevioside] v 3,535 +/- 282 [control] pg/mL x 180 minutes, P <.05). In addition, stevioside caused a pronounced suppression of both the systolic (135 +/- 2 v 153 +/- 5 mm Hg; P <.001) and the diastolic blood pressure (74 +/- 1 v 83 +/- 1 mm Hg; P <.001). Bolus injections of stevioside (0.025 g x kg(-1)) did not induce hypoglycemia. Stevioside augmented the insulin content in the beta-cell line, INS-1. Stevioside may increase the insulin secretion, in part, by induction of genes involved in glycolysis. It may also improve the nutrient-sensing mechanisms, increase cytosolic long-chain fatty acyl-coenzyme A (CoA), and downregulate phosphodiesterase 1 (PDE1) estimated by the microarray gene chip technology. In conclusion, stevioside enjoys a dual positive effect by acting as an antihyperglycemic and a blood pressure-lowering substance; effects that may have therapeutic potential in the treatment of type 2 diabetes and the metabolic syndrome. Copyright 2003, Elsevier Science (USA). All rights reserved.
PMID: 12647278 [PubMed - indexed for MEDLINE]
Related Links
• Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. [Phytomedicine. 2002]
• Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty rats. [Metabolism. 2005]
• Antihyperglycemic effects of stevioside in type 2 diabetic subjects. [Metabolism. 2004]
• Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. [Metabolism. 2000]
• Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. [Metabolism. 2004]
See all Related Articles…

Phytomedicine. 2002 Jan;9(1):9-14. Links

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Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats.
Jeppesen PB, Gregersen S, Alstrup KK, Hermansen K.
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark. pbj@mail-telia.dk
Extracts of leaves from the plant Stevia rebaudiana Bertoni have been used in the traditional treatment of diabetes in Paraguay and Brazil. Recently, we demonstrated a direct insulinotropic effect in isolated mouse islets and the clonal beta cell line INS-1 of the glycoside stevioside that is present in large quantity in these leaves. Type 2 diabetes is a chronic metabolic disorder that results from defects in both insulin and glucagon secretion as well as insulin action. In the present study we wanted to unravel if stevioside in vivo exerts an antihyperglycaemic effect in a nonobese animal model of type 2 diabetes. An i.v. glucose tolerance test (IVGT) was carried out with and without stevioside in the type 2 diabetic Goto-Kakizaki (GK) rat, as well as in the normal Wistar rat. Stevioside (0.2 g/kg BW) and D-glucose (2.0 g/kg BW) were administered as i.v. bolus injections in anaesthetized rats. Stevioside significantly suppressed the glucose response to the IVGT in GK rats (incremental area under the curve (IAUC): 648 +/- 50 (stevioside) vs 958 +/- 85 mM x 120 min (control); P < 0.05) and concomitantly increased the insulin response (IAUC: 51116 +/- 10967 (stevioside) vs 21548 +/- 3101 microU x 120 min (control); P < 0.05). Interestingly, the glucagon level was suppressed by stevioside during the IVGT, (total area under the curve (TAUC): 5720 +/- 922 (stevioside) vs 8713 +/- 901 pg/ml x 120 min (control); P < 0.05). In the normal Wistar rat stevioside enhanced insulin levels above basal during the IVGT (IAUC: 79913 +/- 3107 (stevioside) vs 17347 +/- 2882 microU x 120 min (control); P < 0.001), however, without altering the blood glucose response (IAUC: 416 +/- 43 (stevioside) vs 417 +/- 47 mM x 120 min (control)) or the glucagon levels (TAUC: 5493 +/- 527 (stevioside) vs 5033 +/- 264 pg/ml x 120 min (control)). In conclusion, stevioside exerts antihyperglycaemic, insulinotropic, and glucagonostatic actions in the type 2 diabetic GK rat, and may have the potential of becoming a new antidiabetic drug for use in type 2 diabetes.
PMID: 11924770 [PubMed - indexed for MEDLINE]

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Related Links
• Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. [Metabolism. 2003]
• Antihyperglycemic effects of stevioside in type 2 diabetic subjects. [Metabolism. 2004]
• Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty rats. [Metabolism. 2005]
• Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. [Horm Metab Res. 2005]
• Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. [Metabolism. 2000]

See all Related Articles…

Zhonghua Yi Xue Za Zhi (Taipei). 2002 Jan;65(1):1-6. Links

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Antihypertensive effect of stevioside in different strains of hypertensive rats.
Hsu YH, Liu JC, Kao PF, Lee CN, Chen YJ, Hsieh MH, Chan P.
Department of Medicine, Taipei Medical University-Wan Fang Hospital, Taiwan, ROC.
BACKGROUND: Stevioside is a natural sweet-tasting glycoside isolated from the herb Stevia rebaudiana, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used commercially as sugar substitute. Previous study has shown that it can lower blood pressure in anesthetized spontaneously hypertensive rats (SHR). This study was undertaken to evaluate the antihypertensive effect of stevioside in different strains of hypertensive rats and to observe whether there is difference in blood pressure lowering effect. METHODS: Noninvasive tail-cuff method was employed to measure blood pressure. Stevioside at the concentrations of 50, 100 and 200 mg/kg were administered intraperitoneally (ip) to normotensive Wistar-Kyoto rats (NTR), SHR, deoxycorticosterone acetate-salt (DOCA-NaCl) sensitive hypertensive rats (DHR) and renal hypertensive rats (RHR). RESULTS: Significant hypotensive effect of stevioside administered ip was noted in different strains of rats at the dose of 50 mg/kg. When stevioside was increased to the concentrations of 100 and 200 mg/kg, ip, it also caused slow and persistent lowering of blood pressure in SHR and NTR. Data also showed that stevioside given at the concentrations of 100, 200 and 400 mg/kg ip resulted in lowering of blood pressure in SHR dose-dependently. Blood pressure returned to previous levels after the drug was discontinued for 2-3 days. Drinking of 0.1% stevioside solution in mature SHR could have antihypertensive effect and also prevented hypertension in immature SHR. CONCLUSIONS: This study reconfirmed stevioside has hypotensive effect and the effect is more prominent in hypertensive rats.
PMID: 11939668 [PubMed - indexed for MEDLINE]
Related Links
• The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. [Life Sci. 1998]
• Mechanism of the antihypertensive effect of stevioside in anesthetized dogs. [Pharmacology. 2003]
• Inhibitory effect of stevioside on calcium influx to produce antihypertension. [Planta Med. 2001]
• Stevioside effect on renal function of normal and hypertensive rats. [J Ethnopharmacol. 1992]
• A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. [Br J Clin Pharmacol. 2000]
See all Related Articles…